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Engagement of CD47 by soluble ligands or counter receptors modulates various signaling pathways, such as activation of heterotrimeric G proteins. CD47 (CD47 molecule) is a protein-coding gene. Diseases associated with CD47 include neonatal meningitis . GO annotations related to this gene include thrombospondin receptor activity . 2020-07-16 · CD47 is a heavily glycosylated 50 Kd cell surface protein belonging to the immunoglobulin family, originally named integrin-associated protein (IAP) [ 1 ]. It has an extracellular N -terminal IgV domain, five transmembrane domains, and a short C-terminal cytoplasmic tail. Showing subcellular location of CD47 (IAP, MER6, OA3).
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CD47 is found to be overexpressed on tumor cells and act as a don't eat me' signal, which contributes to immune evasion. Macrophages mediated phagocytosis via blockade CD47/SIRPα (signal regulatory protein alpha) interaction was proved to induce effective antitumor immune response. CD47 (integrin-associated protein, IAP) is a ubiquitously expressed cell surface transmembrane glycoprotein interacting with several integrins and regulating their functions. Engagement of CD47 by soluble ligands or counter receptors modulates various signaling pathways, such as activation of heterotrimeric G proteins. CD47 (CD47 molecule) is a protein-coding gene. Diseases associated with CD47 include neonatal meningitis . GO annotations related to this gene include thrombospondin receptor activity .
Crosstalk between colon cancer cells and macrophages via
Undertitel: [Ångestpodden]. Av: Höckerstrand, Ida. Språk: Svenska.
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Eigenschaften des menschlichen Proteins Masse/Länge Primärstruktur: 323 Aminosäuren, 35.214 Da: Bezeichner Externe IDs 2021-01-26 · CD47 deficiency may offer a potential therapeutic approach for preventing myocardial I/R injury. Evidence linking the overexpression of TSP1-CD47 signaling in diabetes to a number of parameters associated with endothelial dysfunction including impaired angiogenesis, cellular senescence and a heightened state of oxidative stress was found. The CD47-null mouse is lethally susceptible to bacterial infections that are of no consequence to wild-type mice because of a delay in neutrophil recruitment and a weakened integrin-dependent oxidative burst response. 33 In vitro data also support roles for CD47 in leukocyte adhesion to endothelium, 12 leukocyte transmigration, 34 and migration of dendritic cells.
Nationell Arkivdatabas. Karta/ritning - Ecklesiastikdepartementet/ utbildningsdepartementet. Förvaras: Riksarkivet. APD-ribosylcyklas 1 · basigiini (fi); B-cellsaktiverande faktor · butyrofiliinit (fi); CD30-ligand · CD40-ligand · CD47-antigener · CD58-antigener · CD70-antigener
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Publiceringsår: 2019. No ratings. Ämnesord: Unga vuxna · Psykisk hälsa · Ångest · Personlig Vi borde vara lyckliga. Av: Höckerstrand, Ida. Språk: Svenska. Publiceringsår: 2019. Klassifikation: Personlig utveckling och träning. Inga betyg satta.
Strategies for targeting CD47 are becoming a hot spot for cancer therapy. The expression of CD47 is exercised by macrophages to make a distinction between “self” or “nonself.” Anti-CD47 antibodies block the interaction between macrophage signal regulatory protein-α (SIRPα) and tumor
CD47 CD47 molecule. Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). 2019-03-06
About InVivoMAb anti-mouse/human/rat CD47 (IAP). The MIAP410 monoclonal antibody reacts with mouse CD47 otherwise known as integrin-associated protein (IAP).
Macrophages mediated phagocytosis via blockade CD47/SIRPα (signal regulatory protein alpha) interaction was proved to induce effective antitumor immune response. CD47 is a protein complex composed of specific integrin, G protein, and cholesterol and is widely expressed on the surface of cell membrane. The ligand for CD47 is the SIRPα chain, a transmembrane protein, whose extracellular region contains three immunoglobulin superfamily-like regions and the N-terminal region mediates binding to CD47. CD47-Directed TTI-622 Elicits Early Efficacy Signals in Relapsed/Refractory Lymphoma Tissue distribution and regulation of CD47 and binding partners . Expression of CD47 in normal cells and cancer.
3 6 9 12. (μg protein / lane) p84.
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Vi borde vara lyckliga - V8-biblioteken
Klassifikation: Personlig utveckling och träning. Vi borde vara lyckliga. Undertitel: [Ångestpodden].